Equipment Model

Rudolph Research Analytical Autopol III (AP111-6W-10)

Description

The Rudolph Research Analytical Autopol III (AP111-6W-10) is a research-grade polarimeter designed for high-precision analysis of optically active substances. It measures optical rotation, specific rotation, and concentration of chiral compounds and supports multi-wavelength and temperature-controlled measurements. This instrument is used extensively in pharmaceutical, chemical, and academic laboratories for both routine and advanced analysis.

Lab

CIF Room No: 3154

Institute

Central Analytical Laboratory

Location

CIF Room No: 3154, Birla Institute of Technology & Science, Vidya Vihar, Pilani, Rajasthan 333031, India

• Applications

  • Pharmaceutical Industry: Determination of enantiomeric excess and concentration of chiral drugs under GMP/GLP compliance.

  • Chemical Synthesis: Stereochemical analysis and process verification of optically active intermediates.

  • Food Industry: Quantification of sugar solutions (e.g., sucrose, glucose) and quality control of sweeteners.

  • Biochemistry: Study of biomolecules such as amino acids, carbohydrates, and glycoproteins.

  • Academic & Industrial Research: Investigations involving conformational changes, mutarotation, and kinetic optical rotation studies.

  • Regulatory Compliance: Suitable for cGMP environments with 21 CFR Part 11 software integration.

• Key Features

  • High-accuracy measurement of optical and specific rotation over a wide concentration and path length range.

  • Multi-wavelength support (up to 6 wavelengths) for wavelength-dependent optical rotation studies.

  • Integrated Peltier-based temperature control for precise thermal regulation.

  • 21 CFR Part 11 compliant software for secure data logging and audit trails.

  • Touchscreen interface with programmable methods and real-time data display.

• Limitations

  • Higher cost due to advanced features and regulatory compliance support.

  • Requires regular calibration and maintenance for maximum precision.

  • Sample preparation (e.g., filtration, degassing) is critical for accurate readings.

  • Limited to optical activity measurements—cannot provide structural data like NMR or MS.

  • Bulkier than basic polarimeters, requiring dedicated benchtop space.